Categorie
Oxaprozina [Inn-Spanish]
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Oxaprozina [Inn-Spanish]
Analogs
Oxaprozina [Inn-Spanish]
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Oxaprozina [Inn-Spanish]
Formule chimique
C18H15NO3
Oxaprozina [Inn-Spanish]
RX lien
http://www.rxlist.com/cgi/generic/oxaproz.htm
Oxaprozina [Inn-Spanish]
FDA fiche
Oxaprozina [Inn-Spanish]
msds (fiche de securite des materiaux)
Oxaprozina [Inn-Spanish]
Synthese de reference
Aucune information disponible
Oxaprozina [Inn-Spanish]
Poids moleculaire
293.317 g/mol
Oxaprozina [Inn-Spanish]
Point de fusion
158 - 159 oC
Oxaprozina [Inn-Spanish]
H2O Solubilite
Insolubles
Oxaprozina [Inn-Spanish]
Etat
Solid
Oxaprozina [Inn-Spanish]
LogP
4.8
Oxaprozina [Inn-Spanish]
Formes pharmaceutiques
Tablet
Oxaprozina [Inn-Spanish]
Indication
Utilisé pour soulager l'inflammation, l'enflure, la raideur et des douleurs articulaires associées à l'arthrite rhumatoïde et l'arthrose.
Oxaprozina [Inn-Spanish]
Pharmacologie
Oxaprozine est un médicament anti-inflammatoires non stéroïdiens (AINS) avec des propriétés analgésiques et antipyrétiques. Oxaprozine est utilisé pour traiter l'arthrite rhumatoïde, l'arthrose, la dysménorrhée, et pour soulager la douleur modérée.
Oxaprozina [Inn-Spanish]
Absorption
Oxaprozine est de 95% après administration orale. Les aliments peuvent réduire le taux d'absorption de l'oxaprozine, mais le degré d'absorption est inchangé. Les antiacides ne modifient pas sensiblement l'ampleur et la vitesse d'absorption de l'oxaprozine.
Oxaprozina [Inn-Spanish]
Toxicite
Oral, souris: DL50 = 1210 mg / kg; orale, lapin: DL50 = 172 mg / kg; voie orale, rat: DL50 = 4470 mg / kg
Oxaprozina [Inn-Spanish]
Information pour les patients
Daypro, like other drugs of its class, can cause discomfort and, rarely, more serious side effects, such as
gastrointestinal bleeding, which may result in hospitalization and even fatal outcomes. Although serious
gastrointestinal tract ulcerations and bleeding can occur without warning symptoms, patients should be alert for the
signs and symptoms of ulcerations and bleeding, and should ask for medical advice when observing any indicative sign
or symptoms. Patients should be apprised of the importance of this follow-up.
Patients should report to their physicians the signs or symptoms of gastrointestinal ulceration or bleeding, skin
rash, weight gain, or edema.
Patients should be informed of the warning signs and symptoms of hepatotoxicity (e.g., nausea, fatigue, lethargy,
pruritus, jaundice, right upper quadrant tenderness, and “flu-like” symptoms). If these occur, patients
should be instructed to stop therapy and seek immediate medical therapy.
Patients should also be instructed to seek immediate emergency help in the case of an anaphylactoid reaction.
In late pregnancy, as with other NSAIDs, Daypro should be avoided because it will cause premature closure of the
ductus arteriosus.
Oxaprozina [Inn-Spanish]
Organismes affectes
Les humains et autres mammifères